The General Council and Board of Governors' decision to establish an exclusive residential school for girls on the 46-acre field—previously known as the Polo Ground and later used as a playground and farmland—left a lasting impression on Mayo College's history.

Mayo College Girls, the "Sister School" of Mayo College, works to realise the founders' original aim. The stone-laying ceremony took place on the 1st of August 1987.

The Mayo College Girls School has constantly been named among the top schools in India by numerous national and international magazines and is accredited with the Indian Certificate of Secondary Education (ICSE).

Mayo Girls School uses a continuous evaluation approach to track progress continuously without subjecting kids to undue pressure from exams.

Given that there are four terms in an academic year, reports are provided to parents four times a year.

These reports show a girl's accomplishments in both extracurricular and co-curricular activities in addition to her academic excellence. The subject teachers, class teachers, housemistress, and teachers of games and activities are responsible for writing these reports.

The Girls' School provides many extracurricular activities for the girls to hone their talents. They help kids develop skills that are essential in life, such as teamwork and leadership. These activities also help students learn about things they might not comprehend in class, like how to work with adults or interact with people from other cultures.

The school provides extracurricular activities like debates, clubs, and sports. It also provides a variety of classes from which the students choose. The school has an excellent library and computer lab with Wi-Fi access.